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KMID : 1161420110140050462
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Journal of Medicinal Food
2011 Volume.14 No. 5 p.462 ~ p.467
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Effect of Ditaxin and Heteranthin and Inhibitory Effect of Ditaxis heterantha Extract on L5178Y Tumor Development in Mice
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Jaramillo-Flores Maria Eugenia
Permady Herry Heriyati
Puebla-Perez Ana Maria
Padilla Eduardo
del Carmen Lugo-Cervantes Eugenia
Delgado-Sauced Jorge Ivan
Ramon-Gallegos Eva
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Abstract
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Ditaxis heterantha seeds are used as spices for flavoring and coloring food. Two new apocarotenoids derived from the seeds, heteranthin and ditaxin, were evaluated for their in vitro cytotoxic effects in murine lymphoma cells lines. Bioabsorption in mice and preventive and antitumor effects of the apocarotenoids were determined. Ditaxin and heteranthin showed cytotoxic effects in vitro against murine malignant cells and normal splenocyte cells. The 50% inhibitory concentration (IC50) for ditaxin in splenocytes was 0.1825?mM; in L5178Y, the IC50 was 0.1923?mM. The heteranthin IC50 in splenocytes was 0.1325?mM; in L5178Y, the value was 0.3889?mM. The maximum ditaxin plasma concentration was found after 2 hours of administration (mean±standard deviation, 7.5±2.05?μg/mL). Oral administration of the D. heterantha extract (100?mg/kg per day) for 14 days after the L5178Y lymphoma cell implantation showed no significant effect compared with groups that were not pretreated. However, tumor inhibition in groups treated intraperitoneally before inoculation with the L5178Y cells showed a significant difference (P<.001) compared with the groups not pretreated.
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KEYWORD
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anti-tumor, apocarotenoids, cytotoxic, ditaxin, Ditaxis heterantha, heteranthin
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